British Society for Immunology Congress 2017 | 4 - 7 December, Brighton UK

Awen Gallimore

Cardiff University, UK

Awen Gallimore is a Professor at the Division of Infection and Immunity, Cardiff University. She gained a DPhil in Professor Andrew McMichael’s laboratory in Oxford, studying the anti-viral role of cytotoxic T cells in SIV infection, subsequently moving to Professor Rolf Zinkernagel’s laboratory to study the correlates of anti-viral immunity. Her current focus is on the regulation of anti-tumour immunity, with a particular focus on regulatory T cells (Treg). The group takes basic research using animal models of cancer through to testing novel immunotherapies in patients with colorectal cancer (CRC). In the case of CRC, the group has found that Tregs are associated with disease progression and a paucity of T cell responses to tumour-associated antigens. Modulation of Treg numbers restores these immune responses, possibly leading to control of disease progression. In the case of mouse models, the group has found that Treg impact on the tumour vasculature and that modulating Treg numbers/activity results in alterations to the vasculature that serve to increase the frequency of tumour-infiltrating T cells and improve control of tumour growth.